Cardiovascular disease constitutes the primary cause of mortality and morbidity worldwide, and represents a group of disorders associated with the loss of cardiac function. The majority of the currently available therapies remain at best palliative (pain management) in nature as the problem of cardiac tissue loss has not yet been addressed by currently available therapies. The key to treating heart disease lies in finding a way to undo the damage to the heart. Researchers are trying several tactics with stem cells to repair or replace the damaged heart tissue caused by congestive heart failure and heart attacks. As an Example in an event of myocardial infarction (Heart Attack), Heart tissue is progressively lost, placing a large burden on remaining heart tissue to maintain physiologic cardiac function. Lost heart tissue is replaced by scar tissue that is critical to prevent cardiac rupture. But the scar tissue will impede with proper cardiac function and is considered a hallmark of heart failure. The cardiac regenerative therapy has emerged as a novel and promising approach which is aimed at improving cardiac function through rejuvenating muscle tissue and minimizing scar tissue. This approach involves the transplantation of healthy and functional bone marrow derived hematopoetic stem cells to promote the renewal of damaged heart cells and repair injured heart tissue.